Microbicide Testing ( EpiVaginal )
The Model
To facilitate the study of vaginal-ectocervical (VEC) toxicity, pathologies, and basic mucosal phenomena, MatTek has developed the EpiVaginal series of tissue models. EpiVaginal tissues are based on normal, human-derived VEC epithelial and dendritic cells (DC). All VEC tissues are cultured on specially prepared cell culture inserts and are multilayered and highly differentiated. The tissues closely parallel native human tissues, thus providing a useful in vitro means to assess toxicity, sexually transmitted infections, and other basic vaginal phenomena. For more information on EpiVaginal, click here.
Technical References
724. DEVELOPMENT OF A COMBINATION MICROBICIDE GEL FORMULATION CONTAINING IQP-0528 AND TENOFOVIR FOR THE PREVENTION OF HIV INFECTION. Ham1, A.S., Ugaonkar2, S.R., Shi3, L., Watson Buckheit1, K., Lakougna2,H., Nagaraja2, U., Gwozdz3, G., Goldman3, L., Kiser2,4, P.F., Buckheit1, R.W.Jr. 1ImQuest BioSciences, Frederick, Maryland 21704, 2Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, 3Particle Sciences, Bethlehem, Pennsylvania 18017, 4Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112. J Pharm Sci, 101, 1423–1435 (2012).
712. PRECLINICAL EVALUATION OF ANTI-HIV MICROBICIDE PRODUCTS: NEW MODELS AND BIOMARKERS. Doncel, G.F., Clark, M.R. CONRAD, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA. Antiviral Research, 88S, S10–S18 (2010).
710. VAGINAL MICROBICIDE GEL FOR DELIVERY OF IQP-0528, A PYRIMIDINEDIONE ANALOG WITH A DUAL MECHANISM OF ACTION AGAINST HIV-1. Mahalingam1, Simmons2, A.P., Ugaonkar2, S.R., Watson3, K.M., Dezzutti4, C.S., Rohan4, L.C., Buckheit3, Jr., R.W. and Kiser1,2, P.F. 1Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah; 2Department of Bioengineering, University of Utah, Salt Lake City, Utah; 3ImQuest BioSciences, Inc., Frederick, Maryland; and 4Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh, Pennsylvania. Antimicrobial Agents and Chemotherapy, 55, 4, 1650–1660 (2011)
665. PRECLINICAL EVALUATION OF UC781 MICROBICIDE VAGINAL DRUG DELIVERY. Clark1, M.R., McCormick2, T.J., Doncel3, G.F., and Friend1, D.R. Department of Obstetrics and Gynecology, Eastern Virginia Medical School, 1Arlington VA, 2West Chester PA, 3Norfolk VA Drug Deliv. and Transl. Res., 1:175–182 (2011).
577. SAFETY TESTING OF SILICONE ELASTOMER MATRIX VAGINAL RINGS CONTAINING UC781 AND TWEEN 80 USING EPIVAGINAL(VEC-606) TISSUES. McConville1, C., Woolfson1, A.D., Elgendy2, H., Friend2, D., Malcolm1, R.K. 1School of Pharmacy, Queens University of Belfast, Belfast, UK 2CONRAD, Arlington, VA, USA. Presented at Microbicide 2010 Meeting, Pittsburgh, PA May 22-15, 2010.
