I. Skin Irritation (OECD TG 439) : Use EpiDerm to determine the skin irritation potential of chemicals or formulations including liquids, solids, gels, lotions, ointments or creams. Skin irritation results are acquired within 3 days.
II. Skin Corrosion (OECD TG 431) : Use EpiDerm to determine the skin corrosion potential of chemicals or formulations including liquids, solids, gels, lotions, ointments or creams. Skin corrosion results are acquired within 1 day.
III. Ocular Irritation :
1. EpiOcular Eye Irritation Test (EIT)
The EpiOcular EIT is an in vitro hazard assessment assay that has the ability to differentiate materials that are ocular non-irritants from materials that ocular irritants. The EIT is applicable to a broad range of organic and inorganic chemicals, and is accepted as OECD TG 492.
2. EpiOcular “Sub-Draize” Ultra-mildness Test
The EpiOcular Ultra-mildness Test is an in vitro risk assessment assay routinely utilized for mild materials for which the Draize test is insensitive. This highly reproducible assay allows for quantifiable discrimination among mild, milder and mildest product formulations.
3. EpiOcular MTT ET-50 (Neat)
This in vitro risk assessment assay is based on the effective time at which a material (applied neat) causes a 50% reduction in tissue viability (ET-50). Based on the ET-50, the test article is categorized into one of 4 classifications ranging from non-irritating to severe/extreme which correspond to groupings of Rabbit Draize Eye Scores (MMAS).
4. EpiOcular MTT ET-50 (Dilution)
Similar to the MTT ET-50 Neat method, this in vitro risk assessment assay is based on the effective time at which a material (diluted to 20% in water) causes a 50% reduction in tissue viability (ET-50). Based on the ET-50, the test article is categorized into one of 4 classifications ranging from non-irritating to severe/extreme which correspond to groupings of Rabbit Draize Eye Scores (MMAS). This method is recommended for surfactant based solutions and is applicable to water-soluble materials with a specific gravity of > 0.95.
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