Psoriasis Drug Screening in vitro
Need a fast and relaible pre-clinical assay for testing your new anit-psoriasis drug formulations?
MatTek`s in vitro Psoriasis human tissue
model privides relevant, human data pre-
clinical drug screening.
The Psoriasis Tissue Model is produced from human psoriatic cells that are reconstructed to form a highly differentiated skin tissue utilizing cutting edge cell culture technology. The tissue model contains keratinocytes and psoriatic fibroblasts which adopt a psoriatic phenotype evidenced by increased basal cell proliferation, and increased expression of psoriasis-associated biomarkers including HBD-2, Psoriasin, Elafin, IL-6, IL-8, GM-CSF, and IP-10.
The Psoriasis Tissue Model is responsive to topical and systemic therapeutics including Calcipotriol, MG217 and Psoriasin Gel.
Advantage of the Psoriasis Model :
* Topical or systemic application of formulations or APIs
* Generate human relevant data assess true tissue response
* Cost- and time-effective tool to assess therapeutic efficacy