Tissue Engineered In Vitro Human Airway Models of Asthma and COPD

INTRODUCTION: Asthma and chronic obstructive pulmonary disease (COPD) are the two leading chronic respiratory diseases in the US. However, reliable in vitro human models are not widely available to researchers attempting to understand asthma and COPD pathogenesis and develop therapeutic interventions for these diseases. Here we report on a program to create and maintain a human cell bank derived from airway epithelium of diseased individuals, and production of tissue engineered in vitro human models of asthma and COPD from the cells.

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