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MatTek Corporation is pleased to announce the
launch of its new in vitro Psoriasis Tissue Model. The tissue model consists
of normal, human-derived epithelial cells and fibroblasts from psoriatic tissue
which have been cultured to form a multilayered, highly differentiated model of
human psoriasis–like tissue. The Psoriasis Tissue Model exhibits increased
levels of psoriasis associated markers such as basal cell proliferation (Ki67),
human beta defensin-2 (HBD2), SKALP/elafin, psoriasin, and activated STAT3 and
elevated cytokine release (IL-8, IL-6, GM-CSF, and IP-10). The tissue model is
also responsive to therapeutics such as Calciptriol Hydrate.