| Knowledge of acute inhalation toxicity and irritation potential is important for
establishing safe handling, packaging, labeling, transport and emergency response
procedures for chemicals. The US EPA High Production Volume Chemical Challenge,
and the EU REACH programs have further increased the need for inhalation toxicity
A UN treaty endorsed by the US, EU and others outlines a "Globally Harmonized
System” (GHS) of Classification and Labeling of Chemicals. The GHS specifies 5
inhalation toxicity categories. The EPA has established a separate system that uses 4
Acute inhalation toxicity tests currently accepted within the GHS and EPA systems
involve in vivo 4 hr rat inhalation LC50 tests (OECD TG 403/436). In the current work,
a newly developed in vitro toxicity test was evaluated in comparison to the
established in vivo tests.
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